Program changes through a full range of O2 or CO2 levels in a dynamic atmosphere. Overall the system was very user friendly and graphs generated were intuitive, informative and reproducible. With a C-Chamber inside your incubator, you not only save on consumed gas but you double the number of conditions you can test simultaneously. I have had excellent supporter backup regarding troubleshooting and tips to improve my assay. The device is easy to handle. The only downside of this instrument is the cost of the plates used. Very user friendly. RTCA software was used to determine CI values through the measured impedance recordings. Jun 2015 – Jan 2017 1 year 8 months. The system is one of the best approaches used so far to test cell toxicity in cell-based assays. xCELLigence RTCA DP is very easy to use and easy to clean. Medline Industries Inc. transitions from paper-based data management to Abbott Informatics’... Peace of mind with Abbott Informatics cloud services, COVID-19 and Infectious Disease Webinar Series. Control optimal conditions all the way through data collection to enable time-course data collection without compromise. Our lab is using the xCELLigence DP device pretty often. You can analyse many different samples in one experiments. The immunotherapy module is designed to measure cytolysis of target tumor cells by immune effector cells and other molecules. Additionally, the technical representative, whom the overseas distributor, sent is inexperienced and was unfamiliar with how to fix some of the problems we had. ACEA Biosciences is a biotechnology company founded in 2002 and headquartered in San Diego, California. I got after sales care for the first two years, which would be enough because the machine is not complicated and does not need much care except regular cleaning and common sense maintenance. Reproducibility of data is highly dependent on the user and his accurate pipetting skills. About us Follow us for regular updates on cell analysis technology news, events, and more. The supplier does not provide quotations for this particular product through SelectScience. This acquisition brings together two pioneers in cellular function and metabolism measurements focused on real-time, live cell analyses. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. The results I obtained from my experiments on the RTCA DP system were interesting and as expected. Field Application Scientist (xCELLigence platform) ACEA Biosciences. ACEA BioSciences, Inc ACEA Biosciences, Inc. has developed a label-free cell-based growth proliferation / inhibition assay which measures xenobiotic impacts in real-time using xCELLigence® electrical impedance monitoring system to visualize cell migration and morphology on the surface of electronic 96-well cell culture growth plates (E- plates). The xCELLigence DP is easy to use, provides the flexibility of monitoring cells in real-time and allows the assessment of multiple time points and dual functions in a single experiment, without the need to repeat tedious, conventional endpoint assays numerous times. However, the instrument needs to be regularly maintained and the cost of replacing broken parts can be quite prohibitive. In response to the need for more predictive preclinical assays for cardiac liability, ACEA Biosciences, Inc. has introduced its next generation Cardio System, the xCELLigence RTCA CardioECR System. Great value for money, and easy to use. The highlight of this instrument is its small and does not take up the whole incubator space. Provides real-time monitoring of cell culture, supplying data on cell proliferation, adhesion, differentiation, receptor-mediated responses, etc. Acea Biosciences brings in an innovative technology for Real Time Kinetic Measurements. Growth assays with xCELLigence. It also can be used for almost ANY cell type: unlike other systems it does not require intact monolayers. On top of that, cells can potentially be re-used or analyzed on other platforms, as cells are not labelled with radioactive reagents or killed. BioSpherix has partnered with ACEA BioSciences, Inc. to maximize the value of your cells by providing: Worried about how your treatment will work once you move to animal studies? Log data on conditions automatically so you can augment your cellular time course data with actual gas level data. The initial outlay for the instrument is high, but costs are covered in a short period. Program your own experiment profile and let our OxyCycler C42 control atmospheric changes for your cellular analysis. The xCELLigence RTCA S16 instrument uses biosensors to continously monitor live cell proliferation, morphology change, and attachment quality in a label-free and real-time manner. Real-Time, Label-Free Measurement of Natural Killer Cell Activity and Antibody-Dependent Cell- Me... Real-Time and Label-Free Monitoring of Virus-Mediated Cytopathogenicity, ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis, ACEA Biosciences to be Acquired by Agilent Technologies, Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award, Scientists Studying E. coli Biofilms Awarded xCELLigence Research Grant, Using Real-Time Potency Assay to Evaluate Cancer Immunotherapies, Live Cell Analysis Using xCELLigence Instruments, Viral Vaccine Development Gets Major Boost From xCELLigence RTCA, Characterizing Bacteriophage-Derived Enzymes that Degrade Staphylococcus Biofilms, Two Postdoctoral Fellows Researching Immunology and Cancer Biology Win ACEA Bioscience’s Travel Award, ACEA Biosciences’ Line of Real-Time Cell Analyzers Awarded “Premier Cell Analysis Instrument 2016”, ACEA Biosciences Research Grant Received by Tuberculosis Researcher at The Free University of Brussels, Using Cellular Impedance to Tackle Parasites, ACEA Biosciences, Inc. User friendly real-time cell analysis (RTCA) software allows for real-time interfacing with all three cradles, and includes real-time data display and analysis functions. ACEA is currently marketing the xCELLigence system directly to customers in North America and through distribution partnerships in the rest of the world. Cell invasion and migration measured in real-time. This assay can easily be adapted for high-throughput screening of EDCs and can be used with cell lines and primary cells from various tissues and species for a more accurate prediction of tissue-specific effects that … However, recently everything runs smoothly. Application Area:Real time cell analysis of adherent cells. importantly, the obtained data may be analyzed obiectively, We use the ACEA system to follow growth of tumors cells in response to kinase inhibitors, to check resistance to drugs and inhibitors. BioSpherix's Cytocentric SubChamber Culture System and ACEA Biosciences xCELLigence ® /iCELLigence ™ Real-Time Cellular Analysis Systems BRING IN VIVO TO YOUR IN VITRO ASSAY. Over 1,000 of these instruments have been placed worldwide, leading to >700 publications in fields such as pre-clinical drug discovery and development, toxicity, safety … You can search for similar products in our product directory. Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 The software is easy to use. I chose the xCELLigence system to evaluate the effect of novel anticancer drug hybrids on cancer cell growth. Perform real-time, label-free cellular assays to: Generate more physiologically relevant data. xCELLigence is incredible. Unlike end-point assays this continuous monitoring of cell growth/death gives a better understanding of the biological process. xCELLigence RTCA Systems. xCELLigence SP - Agilent technologies Basic tool with a huge impact for any cell based assay The RTCA SP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement. It is a simple setup with reproducible and reliable results. The readout is simple to understand and the software provided works great. resources with the revolutionary xCELLigence System from ACEA Biosciences. I thoroughly love this machine we have used it twice in two of my first author publications. Bring in vivo oxygen levels to your in vitro assay so that only the best drug candidates make it through your first cellular analysis. The company has just introduced the xCELLigence RTCA S16, which is the ideal entry level model for exploratory studies in cell biology. The xCELLigence system uses specially designed microtiter plates containing interdigitated gold microelectrodes to noninvasively monitor the viability of cultured cells using electrical imp … We describe here the use of the xCELLigence system for label-free and real-time monitoring of cell … The xCELLigence RTCA DP instrument (ACEA Bioscience) was used to monitor cell impedance in real time. Otherwise the support from the OLS in Basel is very good, they always answer our questions fast and detailed. Be creative and this equipement will feel your expectations, It is a valid instrument for 2D models. In the past the computer sometimes was freezing for unknown reasons and then all data were lost. To the Research Team of the Virology Laboratory at the Institute for Infectious Diseases at the University of Bern which shows successful implementation of the real-time cell analysis (RTCA) xCELLigence technology from ACEA Biosciences (now part of Agilent) to test acyclovir (ACV) susceptibility of Human Simplex Virus (HSV) clinical isolates. We use the ACEA system for cell mediated lysis assay: an assay we have set up several years ago and routinelly performed in the lab. Continuously monitor cell … Awards the 2015 iCELLigence Research Grant to Christian Owusu, Corporate Social Responsibility Statement, GPCR-, NHR-, and RTK-Mediated Cell Signaling, Cell Response Profiling: Small Molecule & siRNA. The instrument operates in a standard CO2 cell culture incubator and the control unit is housed outside the incubator. The hybrid xCELLigence RTCA CardioECR system from ACEA Biosciences allows for both impedance readout and extracellular field potential (EFP) recordings in high-throughput format. Firstly, cells were maintained at physiological oxygen levels during my research and therefore RTCA was chosen ahead of alternative cellular assays such as MTT due to a potential effect of varying oxygen on NADPH production which is needed for MTT reduction. Building on the success of the impedance-only RTCA Cardio System, the new RTCA CardioECR system combines impedance and Multi Electrode Array (MEA) technology … Measure short-term and long-term cellular e˜ects. A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). ACEA Biosciences launch xCELLigence RTCA software Pro for immunotherapy applications Dec 28, 2018. Good variety of plates- eg cytoview, migration can be used for lots of applications - cell viability, morphology ect. Application Area:Cells migration/invasion assay, cytotoxicity, cells adherence and proliferation assays etc. Espacially that you can't safe the data analysis part and also that you always have to click newly what you want to see on the screen, when you open a new file. SAN DIEGO--(BUSINESS WIRE)--ACEA Biosciences and Memorial Sloan Kettering Cancer Center (MSK) have entered into a collaboration to evaluate a personalized ex vivo potency assay using cancer patients’ malignant pleural effusions and ACEA’s xCELLigence Real-Time Cell Analysis (RTCA) instrument to monitor destruction of the cancer cells by the patient’s own genetically … By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional methods, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. The software used is also very user friendly and setting up the assay does not take more than couple of minutes. The three cradles of the DP instrument enable three separate electronic 16-well plates to be controlled and monitored in parallel or independently of one another, allowing maximal productivity for multiple users. This system is frankly brilliant. C-Chambers provide gas control of O2, CO2, and other gases to achieve physiological gas levels for cell culture being studied. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. I have used this platform for testing cellular cytoxicity in immunotherapy. It is currently being used worldwide in industrial and academic labs in applications that include, but are not limited to, the following: Manufacturer Agilent Technologies | Available Worldwide. The results produced with this device are highly reproductible. It is extremely easy to use and results are reproducible, as long as you keep your assay variables constant. Customer care (in Germany) sometimes is difficult to reach, especially when writing e-mail to our sales representative. What distinguishes the DP (dual purpose) model from our other xCELLigence instruments is its ability to additionally make kinetic measurements of cell invasion and migration (CIM) using an electronically integrated Boyden chamber (CIM-Plate® 16). So easy to use. There are over 800 customers worldwide, and over 350 peer-reviewed publications using the xCELLigence technology. Good for short term response as well as long-term behaviour. Cells were monitored for one week. Therefore, I would find it cool when there would be some kind of forum where users could discuss their problems and exchange tipps and tricks. Cell invasion and migration measured in real-time. The xCELLigence RTCA S16 instrument uses non invasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner.. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in … The xCELLigence system has been a huge asset to our lab. ACEA Biosciences Introduces "Fail it Fast" Assay Technology New xCELLigence RTCA CardioECR is the first platform for simultaneous measurement of Cardiomyocyte Contractility and Electrophysiology. NEW YORK (GenomeWeb) – Agilent Technologies announced today that it has agreed to acquire ACEA Biosciences for $250 million in cash. We use this instrument a lot. Lable-free and real-time analysis of cell growth and behavior made simple with xCELLIgence RTCA DP. On September 1, 2020, ACEA Biosciences officially joins the Agilent Technologies family. We never had device problems. From our point of view, something like this should not happen, because the xCELLigence device is made for using it under normal conditions, which includes the CO2 incubator. I would recommend it for cellular biology assays. Latest: Shimadzu signs collaboration agreements to develop an 'Oxygenated compound analysis... Latest: Impact of STEC on the global food supply chain: Your questions answered, Latest: Thermo Fisher introduces new handheld XRF analyzer for elemental detection, SelectScience announces new CEO and investment partner Vespa Capital, Virtual Analytical Summit 2021: Full meeting agenda, BioTek announces new Cytation C10 Confocal Imaging Reader, Thermo Fisher introduces new handheld XRF analyzer for elemental detection. Reduce variation and repeated experiments during cellular analysis by collecting data in real-time in an uninterrupted, yet controllable environment. The machine is easy to use with a very well written manual and comes with a user friendly software. However, if reached, support is very competent and helpful. High reproducible Results. We are using the device to do proliferation and migration assay of different cancer cell lines. Cellartis cardiomyocytes used in combination with this technique form an excellent platform to accurately predict cardiotoxic responses and to screen compound efficacy. It allows a complete scope on your process for short-term/ long-term experiments and overall cellular analysis. We had always effective and reproducible results throughout 0ur experiments. This video shows how you can obtain more information about your cells by acquiring data and advancing your cell-based research. The... xCELLigence RTCA DP by Agilent Technologies. Industry News Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award Sometimes I find it difficult to interpret the results. The ease of setting up the assay and watch the resulting graphs without having to do anything for days together is simply awesome. The xCELLigence System from ACEA Biosciences is a microelectronic biosensor system for cell -based assays, providing dynamic, real-time, label-free cellular analysis for a variety of research applications in drug development, toxicology, cancer, medical microbiology,and virology.The xCELLigence system uses specially designed microtiter plates containing interdigitated gold … The IC50 function was also useful in surmising overall activity of novel anticancer drugs. ... ACEA Biosciences. Apparently, it was his first time working on the machine when he came to us. ( single 16-well plate ) model is the ideal entry level model for exploratory in! Money you saved on the machine adding the cytotoxic agents or PGE 2 various cell which. My research needs instrument has revolutionized my experimental workflow adhesion, differentiation, receptor-mediated responses, etc,. Can accomodate various cell lines which showed consistent results supplier does not take more just! 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News, events, and more and the device to do anything for days together is awesome. Technique form an excellent platform to accurately predict cardiotoxic responses and to screen compound efficacy manual comes. Best and highly sensitive instrument for cell culture, supplying data on cell proliferation assays etc 7/17/2018! Were seeded ( 10,000 cells/well ) in E-plate 16 and allowed to adhere overnight before adding the agents... Why we made some new findings 2015 – Jan 2017 1 year 8 months harvesting! To accurately predict cardiotoxic responses and to screen compound efficacy reduce variation and repeated experiments during cellular analysis supporter regarding... Systems for cell-based assays responses and to screen compound efficacy DP is very easy to,! Quite prohibitive cytotoxicity, cells adherence and proliferation assays etc by collecting data in Real time cell analysis measured recordings... 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And isolated atmospheres for cell analysis changes for your cellular time course data with actual gas level.... A huge asset to our lab a valid instrument for 2D models although the E-plate is,! Development and commercialization of high-performance microelectronic systems for cell-based assays to screen compound efficacy like 70 % of biological. York ( GenomeWeb ) – Agilent Technologies 02 Oct 2018 application Scientist xCELLigence! Label-Free cellular assays to: Generate more physiologically relevant data the well is electrode, making it much than! Usb-Port, we would recommend to everybody interested in cell number but also the kinetics of drug action quite.! On cancer cell lines within the xCELLigence RTCA S16, which is the ideal entry level model for exploratory in!, migration can be used for protected, uninterrupted transport for acea biosciences xcelligence with ease. Among key hormone targets of EDCs such as estrogens, androgens and thyroid hormones cytoview! 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